Cutaneous siderosis after extravasation of intravenous iron infusion

Experimental ocular siderosis after extrabulbar administration of iron.

The authors studied the penetration of iron administered extrabulbarly into the ocular tissues of rabbits. It was found that iron passes from the orbit into the eyeball and accumulates in considerable quantities in the sclera, choroid, retina, ciliary body, and even in the vitreous and corneal epithelium. However, light microscopy failed to show any damage to the ocular tissues. The mechanism b...

A Case of Skin Necrosis after Extravasation of Intravenous Immunoglobulin

Extravasation of certain drugs can make an injury on the injection site. It occurs more often in the fragile skin of children and old people. Immunoglobulin treats immune-mediated diseases effectively, such as a primary deficiency of antibodies or autoimmune diseases. A 9 months old boy came to hospital complaining of a fever for 5 days. He had bilateral non-purulent conjunctival injection, ery...

Anaphylaxis after intravenous infusion of dexketoprofen trometamol

Dexketoprofen trometamol (DT), a nonsteroidal anti-inflammatory drug, is a highly water-soluble salt and active enantiomer of rac-ketoprofen. Its parenteral form is commonly used for acute pain management in emergency departments of our country. Side effects such as diarrhea, indigestion, nausea, stomach pain, and vomiting may be seen after the use of DT. Anaphylactic shock (AS) secondary to in...

Pharmacology of aztreonam after intravenous infusion.

The pharmacokinetics of aztreonam, a monocyclic beta-lactam which inhibits most members of the family Enterobacteriaceae at concentrations of less than 1 microgram/ml and most Pseudomonas aeruginosa isolates at concentrations of less than 16 micrograms/ml, were examined in healthy male volunteers after 30-min intravenous infusions of 0.5, 1, and 2 g of the drug. Mean peak levels of the drug in ...

Reactions to Total Dose Intravenous Infusion of Iron Dextran (imferon).